Dataset Information

Magnetotrichography: Measuring the dc magnetic field produced by hair follicles.

ABSTRACT: We here describe the dc magnetic field over the human head produced by healthy hair follicles when the scalp is lightly pressed. This phenomenon was briefly reported decades earlier, where a double-planar SQUID (Superconducting Quantum Interference Devices) gradiometer at a single location was used. We here perform a larger study, using the dcMEG containing 102 double-planar gradiometers covering the whole scalp. The field is displayed as an on-line arrow map over the head, showing the approximate flow of direct current (dc) in the scalp. Standard sets of five arrow maps per subject were measured, where the subject successively pressed parts of their head against the inside of the helmet. These maps were made for 15 normal subjects (5 females), and 2 with alopecia (non-functioning follicles). The directions of "pressed" generating arrows always followed the natural tilt of the follicles, verifying the follicles as generators, with a time constant of about one second. The maximum generator dipole strength was about 24 µA-cm. Scalp electric potentials corresponding to the magnetic signals were masked by much larger electrodermal potentials. Therefore, this magnetic method, called magnetotrichography, is unique in measuring this follicular electrical activity, with possible applications in studying baldness and hair diseases.

SUBMITTER: Khan S

PROVIDER: S-EPMC6821812 | biostudies-other | 2019 Oct

REPOSITORIES: biostudies-other

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Magnetotrichography: Measuring the dc magnetic field produced by hair follicles.

Khan Sheraz S Cohen David D

Scientific reports 20191030 1

We here describe the dc magnetic field over the human head produced by healthy hair follicles when the scalp is lightly pressed. This phenomenon was briefly reported decades earlier, where a double-planar SQUID (Superconducting Quantum Interference Devices) gradiometer at a single location was used. We here perform a larger study, using the dcMEG containing 102 double-planar gradiometers covering the whole scalp. The field is displayed as an on-line arrow map over the head, showing the approxima ...[more]

PMID: 31666670

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Project description:PURPOSE:Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector. METHODS AND MATERIALS:BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with ?-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor. A time course analysis was performed histologically and hair growth was observed 14 or 15 days after depilation. Skin specimens were analyzed by DNA microarrays and Western blotting. RESULTS:Telogen irradiation at 6 Gy resulted in transient cell growth arrest, leading to successful hair growth, whereas anagen irradiation failed to promote hair growth. Telogen irradiation did not induce apoptosis in HFs or reduce HF stem cells, whereas anagen irradiation induced apoptosis and reduced stem cell numbers. The Inhibition of FGF receptor signaling during the telogen phase promoted HF cell proliferation; however, hair failed to grow after irradiation. In contrast, recombinant FGF18 induced transient cell growth arrest after anagen irradiation with enhanced DNA repair, leading to the inhibition of apoptosis, maintenance of HF stem cells, and successful hair growth. Moreover, FGF18 reduced the expression levels of genes promoting G2/M transition as well as the protein expression levels of cyclin B1 and cdc2 in skin, and induced G2/M arrest in the keratinocyte cell line HaCaT. CONCLUSIONS:These results suggest that FGF18 signaling mediates radioresistance in telogen HFs by arresting the cell cycle, and that FGF18 has potential as a radioprotector for radiation-induced alopecia.

Dataset Information

Magnetotrichography: Measuring the dc magnetic field produced by hair follicles.

Publications

Magnetotrichography: Measuring the dc magnetic field produced by hair follicles.

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