Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host.
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ABSTRACT:
SUBMITTER: Perry WJ
PROVIDER: S-EPMC6825271 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Publications
<i>Staphylococcus aureus</i> exhibits heterogeneous siderophore production within the vertebrate host.
Perry William J WJ Spraggins Jeffrey M JM Sheldon Jessica R JR Grunenwald Caroline M CM Heinrichs David E DE Cassat James E JE Skaar Eric P EP Caprioli Richard M RM
Proceedings of the National Academy of Sciences of the United States of America 20191014 44
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of <i>Staphylococcus aureus</i> siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly ...[more]
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