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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host.


ABSTRACT: Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Staphylococcus aureus siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.

SUBMITTER: Perry WJ 

PROVIDER: S-EPMC6825271 | biostudies-other | 2019 Oct

REPOSITORIES: biostudies-other

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<i>Staphylococcus aureus</i> exhibits heterogeneous siderophore production within the vertebrate host.

Perry William J WJ   Spraggins Jeffrey M JM   Sheldon Jessica R JR   Grunenwald Caroline M CM   Heinrichs David E DE   Cassat James E JE   Skaar Eric P EP   Caprioli Richard M RM  

Proceedings of the National Academy of Sciences of the United States of America 20191014 44


Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of <i>Staphylococcus aureus</i> siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly  ...[more]

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