Ontology highlight
ABSTRACT:
SUBMITTER: Gu L
PROVIDER: S-EPMC6831865 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Gu Linlin L Larson Casey Jennifer L JL Andrabi Shaida A SA Lee Jun Hee JH Meza-Perez Selene S Randall Troy D TD Carter A Brent AB
Redox biology 20190825
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an increased mortality. Metabolic reprogramming has a critical role in multiple chronic diseases. Lung macrophages expressing the mitochondrial calcium uniporter (MCU) have a critical role in fibrotic repair, but the contribution of MCU in macrophage metabolism is not known. Here, we show that MCU regulates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and metabolic reprogramming to fatty acid oxida ...[more]