The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate

ABSTRACT: During infection viruses hijack host cell metabolism to promote their replication. Here, analysis of metabolite alterations in macrophages exposed to poly I:C recognises that the antiviral effector Protein Kinase RNA-activated (PKR) suppresses glucose breakdown within the pentose phosphate pathway (PPP). This pathway runs parallel to central glycolysis and is critical to producing NADPH and pentose precursors for nucleotides. Changes in metabolite levels between wild-type and PKR-ablated macrophages show that PKR controls the generation of ribose 5-phosphate, in a manner distinct from its established function in gene expression but dependent on its kinase activity. PKR phosphorylates and inhibits ribose 5-phosphate isomerase (RPIA), preventing interconversion of ribulose- to ribose 5-phosp

SUBMITTER: Dr. Pushpak bhattacharjee 

PROVIDER: S-SCDT-10_1038-S44318-024-00100-W | biostudies-other |

REPOSITORIES: biostudies-other