Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration

ABSTRACT: Tumor necrosis factor receptors (TNFRs) control pleiotropic pro-inflammatory functions that range from apoptosis to cell survival. The ability to trigger a particular function will depend on the upstream cues, association with regulatory complexes, and downstream pathways. In Drosophila melanogaster, two TNFRs have been identified, Wengen (Wgn) and Grindelwald (Grnd). Although several reports associate these receptors with JNK-dependent apoptosis, it has recently been found that Wgn activates a variety of other functions. We demonstrate that Wgn is required for survival by protecting cells from apoptosis. This is mediated by dTRAF1 and results in the activation of p38 MAP kinase. Remarkably, Wgn is required for apoptosis-induced regeneration and is activated by the reactive oxygen species

SUBMITTER: Mr. José Esteban-Collado 

PROVIDER: S-SCDT-10_1038-S44318-024-00155-9 | biostudies-other |

REPOSITORIES: biostudies-other