Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1

ABSTRACT: RETINOBLASTOMA-RELATED (RBR) proteins orchestrate cell division, differentiation, and survival in response to environmental and developmental cues through protein-protein interactions that are governed by multi-site phosphorylation. Here we explore, using a large collection of transgenic RBR phospho-variants to complement protein function in Arabidopsis thaliana, whether differences in the number and position of RBR phosphorylation events cause a diversification of the protein's function. While the number of point mutations influence phenotypic strength, phospho-sites contribute differentially to distinct phenotypes. RBR pocket domain mutations associate primarily with cell proliferation, while mutations in the C-region are linked to stem cell maintenance. Both phospho-mimetic and a phosph

SUBMITTER: Jorge Zamora-Zaragoza 

PROVIDER: S-SCDT-10_1038-S44318-024-00282-3 | biostudies-other |

REPOSITORIES: biostudies-other