A double-agent microRNA regulates viral cross-kingdom infection in animals and plants

ABSTRACT: Plant arbovirus infection is regulated by a delicate interplay between virus, vector, and host. While microRNAs are known to be transmitted across species, their role as cross-kingdom effectors in influencing arbovirus infectious cycles remains poorly understood. Our study reveals the dual role of miR-263a, a conserved insect microRNA, in governing rice stripe virus (RSV) infection within both insect vector, small brown planthopper, and rice host. In the planthopper, miR-263a facilitates rice stripe virus accumulation through targeting a cathepsin B-like gene to inhibit apoptosis in midgut epithelial cells. Upon insect saliva secretion, miR-263a is delivered into rice, where it proceeds to upregulate the transcription factor GATA19, triggering an antiviral response. The increase of GATA19

SUBMITTER: Feng Cui 

PROVIDER: S-SCDT-10_1038-S44318-025-00405-4 | biostudies-other |

REPOSITORIES: biostudies-other