Genetic linkage disequilibrium of deleterious mutations in threatened mammals

ABSTRACT: The impact of negative selection against deleterious mutations in endangered species remains underexplored. Recent studies have measured mutation load by comparing the accumulation of deleterious mutations, however, this method is most effective when comparing within and between populations of phylogenetically closely-related species. Here, we introduced new statistics, LDcor and its standardized form nLDcor, which allows us to detect and compare global linkage disequilibrium of deleterious mutations across species using unphased genotypes. These statistics measure averaged pairwise standardized covariance and absolute covariance, respectively, and help to standardize mutation differences based on allele frequencies to reflect selection intensity. We then examined selection strength in gen

SUBMITTER: Chunyan Hu 

PROVIDER: S-SCDT-10_1038-S44319-024-00307-2 | biostudies-other |

REPOSITORIES: biostudies-other