Experience-driven development of decision-related representations in the auditory cortex

ABSTRACT: Associating sensory stimuli with behavioral significance induces substantial changes in stimulus representations. Recent studies suggest that primary sensory cortices not only adjust representations of task-relevant stimuli, but actively participate in encoding decision-making features. We sought to determine whether this trait is innate in sensory cortices or if choice representation develops with time and experience. To trace choice representation development, we perform chronic two-photon calcium imaging in the primary auditory cortex of head-fixed mice while they gain experience in a tone detection task with a delayed decision window. Our results reveal a progressive increase in choice-dependent activity within a specific subpopulation of neurons, aligning with growing task familiarity

SUBMITTER: Dr. Jennifer Resnik 

PROVIDER: S-SCDT-10_1038-S44319-024-00309-0 | biostudies-other |

REPOSITORIES: biostudies-other