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A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery


ABSTRACT: Achieving complete tumor resection is challenging and can be improved by real-time fluorescence guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is traditionally performed in animal models and further hampered by inter- and intra-tumoral heterogeneity in target expression. To screen multiple probes at patient scale, we developed a multispectral real-time 3D imaging platform that implements organoid technology to effectively model patient tumor heterogeneity and, importantly, healthy human tissue binding.

SUBMITTER: Dr. Anne, C. Rios 

PROVIDER: S-SCDT-10_1038-S44321-024-00084-4 | biostudies-other |

REPOSITORIES: biostudies-other

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