Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice

ABSTRACT: Di-(2-ethylhexyl) phthalate (DEHP), an environmental pollutant, has been widely detected in both environmental and clinical samples, representing a serious threat to the homeostasis of the endocrine system. The accumulation of DEHP is notably pronounced in the liver and can lead to liver damage. The lack of effective high-throughput screening system retards the discovery of such drugs that can specifically target and eliminate the detrimental impact of DEHP. Here, by developing a Cy5-modified single-strand DNA-aptamer-based approach targeting DEHP, we have identified luteolin as a potential drug, which showcasing robust efficacy in detoxifying the DEHP by facilitating the expulsion of DEHP in both mouse primary hepatocytes and livers. Mechanistically, luteolin enhances the protein degradat

SUBMITTER: Dr. Huiting Wang 

PROVIDER: S-SCDT-10_1038-S44321-024-00160-9 | biostudies-other |

REPOSITORIES: biostudies-other