Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB

ABSTRACT: Melanin-like nanoparticles (MNPs) have emerged as valuable agents in antioxidant therapy due to their excellent biocompatibility and potent ability to scavenge reactive oxygen species (ROS). However, their potential in chronic conditions remains underexplored. This study synthesized ultra-small polyethylene glycol-incorporated Mn2+-chelated MNPs (MMPP) and found that MMPP crosses the glomerular filtration barrier and accumulates specifically in renal tubules. Autosomal dominant polycystic kidney disease (ADPKD), a chronic genetic disorder associated with increased oxidative stress and progressive cyst enlargement in renal tubules, was treated with MMPP. MMPP significantly reduced oxidative stress, inhibited cyst growth, and improved renal function. Moreover, MMPP was shown to inhibit a cys

SUBMITTER: Lirong Zhang 

PROVIDER: S-SCDT-10_1038-S44321-024-00167-2 | biostudies-other |

REPOSITORIES: biostudies-other