NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness

ABSTRACT: There is growing evidence that ion channels are critically involved in cancer cell invasiveness and metastasis. However, the molecular mechanisms of ion signaling promoting cancer behavior are poorly understood and the complexity of the underlying remodeling during metastasis remains to be explored. Here, using a variety of in vitro and in vivo techniques we show that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion. We identify the Na+ leak channel, NALCN, which is overexpressed in metastatic prostate cancer, as a major initiator and regulator of Ca2+ oscillations required for invadopodia formation. Indeed, NALCN-mediated Na+ influx into cancer cells maintains intracellular Ca2+ oscillations via a specific chain of ion transport prote

SUBMITTER: Dr. Antoine Folcher 

PROVIDER: S-SCDT-10_15252-EMBJ_2022112198 | biostudies-other |

REPOSITORIES: biostudies-other