LncRNA LITATS1 suppresses TGF-beta-induced EMT and cancer cell plasticity by potentiating TbetaRI degradation

ABSTRACT: Epithelial cells acquire mesenchymal phenotypes through epithelial-mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain their epithelial traits and prevent malignant transformation is not well understood. Here, we report that the long noncoding RNA LITATS1 (LINC01137, ZC3H12A-DT) is an epithelial gatekeeper in normal epithelial cells and inhibits EMT in breast and non-small cell lung cancer cells. Transcriptome analysis identified LITATS1 as a TGF- target gene. LITATS1 expression is reduced in lung adenocarcinoma tissues compared to adjacent normal tissues, and correlates with a favorable prognosis in breast and non-small cell lung cancer patients. LITATS1 depletion promotes TGF--induced EMT, migration and extravasation in cancer cells. Unbiased pa

SUBMITTER: Chuannan Fan 

PROVIDER: S-SCDT-10_15252-EMBJ_2022112806 | biostudies-other |

REPOSITORIES: biostudies-other