Centrosome amplification fine-tunes tubulin acetylation to differentially control intracellular organization

ABSTRACT: Intracellular organelle organization is conserved in eukaryotic cells and is primarily achieved through active transport by motor proteins along the microtubule cytoskeleton. Microtubule post-translational modifications (PTMs) can contribute to microtubule diversity and differentially regulate motor-mediated transport. Here we show that centrosome amplification, commonly observed in cancer and shown to promote aneuploidy and invasion, induces a global change in organelle positioning towards the cell periphery and facilitates nuclear migration through confined spaces. This reorganization requires kinesin-1 and is analogous to loss of dynein. Cells with amplified centrosomes display increased levels of acetylated tubulin, a PTM that could enhance kinesin-1 mediated transport. Depletion of -

SUBMITTER: Dr. Pedro Monteiro 

PROVIDER: S-SCDT-10_15252-EMBJ_2022112812 | biostudies-other |

REPOSITORIES: biostudies-other