A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells

ABSTRACT: The large intestine harbors microorganisms playing unique roles in host physiology. The beneficial or detrimental outcome of host-microbiome coexistence depends largely on the balance between regulators and responder intestinal CD4+ T cells. We found that ulcerative colitis-like changes in the large intestine after infection with the protist Blastocystis ST7 in a mouse model are associated with reduction of anti-inflammatory Treg cells and simultaneous expansion of proinflammatory Th17 responders. These alterations in CD4+ T cells depended on the tryptophan metabolite indole-3-acetaldehyde (I3AA) produced by this single cell eukaryote. I3AA reduced the Treg subset in vivo and iTreg development in vitro by modifying their sensing of TGFβ, concomitantly affecting recognition of self-flora an

SUBMITTER: Prof. Nicholas, R.J. Gascoigne 

PROVIDER: S-SCDT-10_15252-EMBJ_2022112963 | biostudies-other |

REPOSITORIES: biostudies-other