Global histone H2B degradation regulates insulin/IGF signaling-mediated nutrient stress

ABSTRACT: Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic landscapes and transcriptional programs. Nucleosomal histones carry vital epigenetic information and regulate gene expression, yet the mechanisms underlying chromatin-bound histone exchange remain elusive. Here, we found that histone H2Bs are globally degraded in Caenorhabditis elegans during starvation. Our genetic screens identified mutations in ubiquitin and ubiquitin-related enzymes that block H2B degradation in starved animals, identifying lysine 31 as the crucial residue for chromatin-bound H2B ubiquitination and elimination. Retention of aberrant nucleosomal H2B increased the association of the FOXO transcription factor DAF-16 with chromatin, generating an ectopic gene expression profile detrimenta

SUBMITTER: Dr. Zhiwen Zhu 

PROVIDER: S-SCDT-10_15252-EMBJ_2022113328 | biostudies-other |

REPOSITORIES: biostudies-other