The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties

ABSTRACT: Growing evidence suggests that the corticotropin-releasing hormone (CRH) signaling pathway, mainly known as a critical initiator of humoral stress responses, has a role in normal neuronal physiology. However, despite the evidence of CRH receptor (CRHR) expression in the embryonic ventricular zone, the exact functions of CRH signaling in embryonic brain development have not yet been fully determined. In this study, we show that CRHR1 is required for the maintenance of neural stem cell properties, as assessed by in vitro neurosphere assays and cell distribution in the embryonic cortical layers following in utero electroporation. Identifying the underlying molecular mechanisms of CRHR1 action, we find that CRHR1 functions are accomplished through increasing expression of the master transcript

SUBMITTER: Mookwang Kwon 

PROVIDER: S-SCDT-10_15252-EMBR_202255313 | biostudies-other |

REPOSITORIES: biostudies-other