ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

ABSTRACT: Several homeoprotein transcription factors transfer between cells and regulate gene expression, protein translation, and chromatin organization in recipient cells. ENGRAILED-1 is one such homeoprotein expressed in spinal V1 interneurons that synapse on α-motoneurons. Neutralizing extracellular ENGRAILED-1 by expressing a secreted single-chain antibody blocks its capture by spinal motoneurons resulting in α-motoneuron loss and limb weakness. A similar but stronger phenotype is observed in the Engrailed-1 heterozygote mouse, confirming that ENGRAILED-1 exerts a paracrine neurotrophic activity on spinal cord α-motoneurons. Intrathecal injection of ENGRAILED-1 leads to its specific internalization by spinal motoneurons and has long-lasting protective effects against neurodegeneration and weakn

SUBMITTER: Dr. Mélanie Leboeuf 

PROVIDER: S-SCDT-10_15252-EMBR_202256525 | biostudies-other |

REPOSITORIES: biostudies-other