Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice

ABSTRACT: Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant L. monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells

SUBMITTER: Dennis Yüzen 

PROVIDER: S-SCDT-10_15252-EMBR_202356829 | biostudies-other |

REPOSITORIES: biostudies-other