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The two-step cargo recognition mechanism of heterotrimeric kinesin

ABSTRACT: Kinesin-driven intracellular transport is essential for various cell biological events and thus plays a crucial role in many pathological processes. However, little is known about the molecular basis of the specific and dynamic cargo-binding mechanism of kinesins. Here, an integrated structural analysis of the KIF3/KAP3 and KIF3/KAP3-APC complexes unveils the mechanism by which KIF3/KAP3 can dynamically grasp APC in a two-step manner, which suggests kinesin-cargo recognition dynamics composed of cargo loading, locking, and release. Our finding is the first demonstration of the two-step cargo recognition and stabilization mechanism of kinesins, which provides novel insights into the intracellular trafficking machinery.

SUBMITTER: Dr. Xuguang Jiang

PROVIDER: S-SCDT-10_15252-EMBR_202356864 | biostudies-other |

REPOSITORIES: biostudies-other

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The two-step cargo recognition mechanism of heterotrimeric kinesin.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-26 | E-GEOD-30389 | biostudies-arrayexpress

Aplysia kinesin mRNA cargo study

Project description:This SuperSeries is composed of the SubSeries listed below.

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