MPFC DUSP1 mediates adolescent cocaine exposure-induced higher sensitivity to drug in adulthood

ABSTRACT: Adolescent cocaine abuse increases the risk for developing addiction in later life, but the underlying molecular mechanism remains poorly understood. Here, we establish adolescent cocaine-exposed (ACE) male mouse models. A subthreshold dose of cocaine (sdC) treatment, insufficient to produce conditioned place preference (CPP) in adolescent mice, induces CPP in ACE mice during adulthood, along with more activated CaMKII-positive neurons, higher dual specificity protein kinase-phosphatase-1 (Dusp1) mRNA, lower DUSP1 activity and lower DUSP1 expression in CaMKII-positive neurons in the medial prefrontal cortex (mPFC). Overexpressing DUSP1 in CaMKII-positive neurons suppresses neurons activity and blocks sdC-induced CPP in ACE mice during adulthood. On the other hand, depleting DUSP1 in CaMKII

SUBMITTER: Ms. Xiaoyan Wei 

PROVIDER: S-SCDT-10_15252-EMBR_202356981 | biostudies-other |

REPOSITORIES: biostudies-other