Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis

ABSTRACT: Intracellular infiltration of bacteria into host cells complicates medical and surgical treatment of bacterial joint infections. Unlike soft tissue infections, septic arthritis and infection-associated inflammation destroy cartilage that does not regenerate once damaged. Herein, we show that glycolytic pathways are shared by methicillin-resistant Staphylococcus aureus (MRSA) proliferation and host inflammatory machinery in septic arthritis. MRSA readily penetrates host cells and induces pro-inflammatory cascades that persist after conventional antibiotic treatment. The glycolysis-targeting drug dimethyl fumarate (DMF) showed both bacteriostatic and anti-inflammatory effects by hindering the proliferation of intracellular MRSA and dampening excessive intraarticular inflammation. Combinatori

SUBMITTER: Prof. Francis, Y. Lee 

PROVIDER: S-SCDT-10_15252-EMMM_202115284 | biostudies-other |

REPOSITORIES: biostudies-other