NPC1 enables cholesterol mobilization during LTP that can be restored in NPC by CYP46A1 activation

ABSTRACT: NPC is a neurodegenerative disorder characterized by cholesterol accumulation in endolysosomal compartments. It is caused by mutations in the gene encoding NPC1, an endolysosomal protein mediating intracellular cholesterol trafficking. Cognitive and psychiatric alterations are hallmarks in NPC patients pointing to synaptic defects. However, the role of NPC1 in synapses has not been explored. We show that NPC1 is present in the postsynaptic compartment and is locally translated during LTP. A mutation in a region of the NPC1 gene commonly altered in NPC patients reduces NPC1 levels at synapses due to enhanced degradation. This leads to shorter postsynaptic densities, increased synaptic cholesterol and impaired LTP in NPC1nmf164 mice with cognitive deficits. NPC1 mediates cholesterol mobiliza

SUBMITTER: Dr. Maria Dolores Ledesma 

PROVIDER: S-SCDT-EMBOR-2019-48143-T | biostudies-other |

REPOSITORIES: biostudies-other