The UPR sensor IRE1? promotes dendritic cell responses to control Toxoplasma gondii infection.

ABSTRACT: The unfolded protein response (UPR) has emerged as a central regulator of immune cell responses in several pathologic contexts including infections. However, how intracellular residing pathogens modulate the UPR in dendritic cells (DCs) and thereby affect T cell-mediated immunity remains uncharacterized. Here, we demonstrate that infection of DCs with Toxoplasma gondii (T. gondii) triggers a unique UPR signature hallmarked by the MyD88-dependent activation of the IRE1? pathway and the inhibition of the ATF6 pathway. Induction of XBP1s controls pro-inflammatory cytokine secretion in infected DCs while IRE1??promotes MHCI antigen presentation of secreted parasite antigens. In mice, infection leads to a specific activation of the IRE1? pathway, which is restricted to the cDC1 subset. Mice def

SUBMITTER: Dr. Anais, F Poncet 

PROVIDER: S-SCDT-EMBOR-2019-49617V1 | biostudies-other |

REPOSITORIES: biostudies-other