Epstein-Barr virus derived circular RNA LMP2A induces stemness in EBV-associated gastric cancer

ABSTRACT: Cancer stem cells (CSCs) are cancer initiating cells that are not only a source of tumorigenesis but also the cause of tumour progression, metastasis and therapy resistance. EBV-associated gastric cancer (EBVaGC) is a distinct subtype of gastric cancer with unique clinicopathological and molecular features. However, whether CSCs exist in EBVaGC, and the tumorigenic mechanism of EBV, remains unclear. Here, NOD/SCID mice were injected subcutaneously with the EBVaGC cell line SNU719 and treated with 5-fluorouracil weekly. Successive generations of xenografts yielded a highly malignant EBVaGC cell line, SNU-4th, which displays properties of CSCs and mainly consists of CD44+CD24- cells. In SNU-4th cells, the expression of an EBV-encoded circRNA, ebv-circLMP2A, is strongly increases, which plays

SUBMITTER: Li, ping Gong 

PROVIDER: S-SCDT-EMBOR-2019-49689V1 | biostudies-other |

REPOSITORIES: biostudies-other