RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity

ABSTRACT: The type I interferon (IFN-I, IFN-?/?)-mediated immune response is the first line of host defense against invading viruses. IFN-?/? binds to IFN-?/? receptors (IFNARs) and triggers the expression of IFN-stimulated genes (ISGs). Thus, stabilization of IFNARs is important for prolonging antiviral activity. Here, we report the induction of an RNA-binding motif containing protein, RBM47, upon viral infection or interferon stimulation. Using multiple virus infection models, we demonstrate that RBM47 has broad-spectrum antiviral activity in vitro and in vivo. RBM47 has no noticeable impact on IFN production, but significantly activates the IFN-stimulated response element (ISRE) and enhances the expression of interferon-stimulated genes (ISGs). Mechanistically, RBM47 binds to the 3'UTR of IFNAR1

SUBMITTER: Dr. Kezhen Wang 

PROVIDER: S-SCDT-EMBOR-2020-52205V1 | biostudies-other |

REPOSITORIES: biostudies-other