Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration

ABSTRACT: Cardiac regeneration occurs primarily through proliferation of existing cardiomyocytes, but also involves complex interactions between distinct cardiac cell types including non-cardiomyocytes (nonCMs). However, the subpopulations, distinguishing molecular features, cellular functions, and intercellular interactions of nonCMs in heart regeneration remain largely unexplored. Using the LIGER algorithm, we assemble an atlas of cell states from 61,977 individual nonCM scRNA-seq profiles isolated at multiple time-points during regeneration. This analysis reveals extensive nonCM cell diversity, including multiple macrophage (MC), fibroblast (FB) and endothelial cell (EC) subpopulations with unique spatiotemporal distributions and suggests an important role for MC in inducing the activated FB and

SUBMITTER: Dr. Hong Ma 

PROVIDER: S-SCDT-EMBOR-2021-52901-T | biostudies-other |

REPOSITORIES: biostudies-other