EGFL7 enhances surface expression of integrin ?

ABSTRACT: Glioblastoma is a typically lethal type of brain tumor with a median survival of 15 months post diagnosis. In an attempt to improve the efficacy of anti-VEGF treatment we explored the role of the egfl7 gene in malignant glioma. We found that the encoded extracellular matrix protein EGFL7 was secreted by glioma blood vessels but not glioma cells, while no major role could be assigned to the parasitic miRNAs miR 126/126*. EGFL7 expression promoted glioma growth in glioma models in vivo and stimulated tumor vascularization. Mechanistically, this was mediated by an upregulation of integrin ?5?1 on the cellular surface of endothelial cells, which enhanced fibronectin-induced angiogenic sprouting. Glioma blood vessels were more mature as determined by pericyte and smooth muscle cell coverage. Fu

SUBMITTER: Ms. Nevenka Dudvarski Stankovic 

PROVIDER: S-SCDT-EMM-2017-08420 | biostudies-other |

REPOSITORIES: biostudies-other