MiRNA Exporter HuR Clears Macrophage Internalized Pathogens by Promoting Pro-inflammatory Response

ABSTRACT: miRNA derepressor protein HuR can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. We have identified how HuR, by inducing extracellular vesicles-mediated export of miRNAs, ensures robust derepression of miRNA-repressed cytokines essential for strong pro-inflammatory response in activated mammalian macrophages. Leishmania donovani, the causative agent of visceral leishmaniasis, on the contrary alters immune response of the host macrophage by a variety of complex mechanisms to promote anti-inflammatory response-essential for its survival. We have found that during Leishmania infection, the pathogen targets HuR to promote onset of anti-inflammatory response in mammalian macrophages. In infected macrophages, Leishmania also upregulate Protein Phosphatase 2A that

SUBMITTER: Dr. Suvendra, N Bhattacharyya 

PROVIDER: S-SCDT-EMM-2019-11011 | biostudies-other |

REPOSITORIES: biostudies-other