Dietary magnesium supplementation improves lifespan in a mouse model of progeria

ABSTRACT: Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant capacity, including loss of the NADPH-coupled glutathione redox system. LmnaG609G/+ mice also exhibited reduced mitochondrial ATP synthesis secondary to ROS-induced mitochondrial dysfunction. Treatment of LmnaG609G/+ vascular smooth muscle cells with magnesium-enriched medium improved the intracellular ATP level, enhanced the antioxidant capacity, and thereby reduced mitochondrial ROS production. Moreover, treatment of LmnaG609G/+ mice with dietary magnesium improved the proton pumps (complex I, III, and IV), stimulated extramitochondrial NADH oxi

SUBMITTER: Dr. Ricardo Villa-Bellosta 

PROVIDER: S-SCDT-EMM-2020-12423 | biostudies-other |

REPOSITORIES: biostudies-other