Systemically Targeted Cancer Immunotherapy and Gene Delivery using Transmorphic Particles.

ABSTRACT: Immunotherapy is a powerful tool for cancer treatment, but the pleiotropic nature of cytokines and immunological agents strongly limit clinical translation and safety. To address this unmet need, we designed and characterised a systemically targeted cytokine gene delivery system through transmorphic encapsidation of human recombinant adeno-associated virus DNA using coat proteins from a tumor-targeted bacteriophage (phage). We show that Transmorphic Phage/AAV (TPA) particles provide superior delivery of transgenes over current phage-derived vectors through greater diffusion across the extracellular space and improved intracellular trafficking. We used TPA to target the delivery of cytokine-encoding transgenes for interleukin-12 (IL12), and novel isoforms of IL15 and tumor necrosis factor

SUBMITTER: Dr. Paladd Asavarut 

PROVIDER: S-SCDT-EMM-2021-15418P | biostudies-other |

REPOSITORIES: biostudies-other