Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Astemizole: Acute Effects on Cardiovascular Functions Following Oral Administration in Conscious, Telemetered Cynomolgus Monkeys (Macaca fascicularis)

ABSTRACT: N=4 male Conscious telemetered Cynomolgus monkeys, dosed with astemizole at 3, 10 and 30 mg/kg ? successively per os. No PK phase. Parameters: haemodynamic parameters (SAP, DAP, MAP, HR), lead II ECG (RR, PR, QRS, QT, QTcB, QTcA and QTcF), body temperature (C?). Parameters were recorded approximately 1.5 hours before administration then at 0.5,1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, 20 and 24 hours after dosing.

ORGANISM(S): Cynomolgus Monkeys

SUBMITTER:

PROVIDER: S-TQST85 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Sotalol: acute effects on cardiovascular functions following oral administration in conscious, telemetered Cynomolgus primates.

Project description: Not available

| S-TQST87 | biostudies-other

Moxifloxacin: Evaluation of effects on blood pressure, heart rate, electrocardiogram and body temperature after single oral dosing in conscious telemetered cynomolgus monkeys (Macaca fascicularis)

Project description: Not available

| S-TQST83 | biostudies-other

Moxifloxacin: A Cardiovascular Safety Pharmacology Study Using Radiotelemetry in Conscious Cynomolgus Monkeys Following Oral Administration

Project description: Not available

| S-TQST84 | biostudies-other

Moxifloxacin: Acute Effects on Cardiovascular Functions Following Oral Administration in the Conscious Telemetered Beagle Dog

Project description: Not available

| S-TQST61 | biostudies-other

Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).

Project description:The Infinium Human Methylation450 BeadChip Array (Infinium 450K) is a robust and cost-efficient survey of genome-wide DNA methylation patterns. Macaca fascicularis (Cynomolgus macaque) is an important disease model; however, its genome sequence is only recently published, and few tools exist to interrogate the molecular state of Cynomolgus macaque tissues. Although the Infinium 450K is a hybridization array designed to the human genome, the relative conservation between the macaque and human genomes makes its use in macaques feasible. Here, we used the Infinium 450K array to assay DNA methylation in 11 macaque muscle biopsies. We showed that probe hybridization efficiency was related to the degree of sequence identity between the human probes and the macaque genome sequence. Approximately 61% of the Human Infinium 450K probes could be reliably mapped to the Cynomolgus macaque genome and contain a CpG site of interest. We also compared the Infinium 450K data to reduced representation bisulfite sequencing data generated on the same samples and found a high level of concordance between the two independent methodologies, which can be further improved by filtering for probe sequence identity and mismatch location. We conclude that the Infinium 450K array can be used to measure the DNA methylome of Cynomolgus macaque tissues using the provided filters. We also provide a pipeline for validation of the array in other species using a simple BLAST-based sequence identify filter.

| S-EPMC4455772 | biostudies-literature

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys.

Project description:The effects of dofetilide were studied in monkeys and dogs. Pharmacokinetic data were generated together with the monitoring of cardiovascular changes in order to compare effects relative to human exposure.Beagle dogs and cynomolgus monkeys were telemetered to collect arterial blood pressure, heart rate and ECG for 6 h after selected oral doses of dofetilide. Pharmacokinetic parameters were determined for each dose.Dogs: increases in the QT(c) interval reached 56 ms in dogs dosed with 0.3 mg kg(-1) of dofetilide. Premature ventricular contractions and right bundle branch block were evident at this dose, without changes in cardiovascular parameters. The mean C(max) values were 3.35 and 60.15 ng mL(-1) at doses of 0.03 and 0.3 mg kg(-1), respectively. Monkeys: increases in QT(c) intervals reached 40-50 ms after 0.03 mg kg(-1). T-wave changes were observed after 0.03 mg kg(-1) without changes in cardiovascular parameters. The mean C(max) values following oral doses of 0.01 and 0.03 mg kg(-1) were 0.919 ng mL(-1) and 1.85 ng mL(-1), respectively.Despite dofetilide exposure comparable to that in humans, QT(c) responses in dogs were greater than those reported in humans. A comparable human dose used in the monkey achieved only half of the exposure but was associated with twofold greater increases in QT(c). Our data support the view that safety risk assessments of new drugs in animal models should ensure that the clinical therapeutic range of exposure is achieved and any untoward effects interpreted accordingly.

| S-EPMC2492096 | biostudies-other

Infinium Monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis)

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-06-05 | GSE53596 | GEO

Infinium Monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-05 | E-GEOD-53596 | biostudies-arrayexpress

The complete genome and genetic characteristics of SRV-4 isolated from cynomolgus monkeys (Macaca fascicularis).

Project description:At least 5 serotypes of exogenous simian retrovirus type D (SRV/D) have been found in nonhuman primates, but only SRV-1, 2 and 3 have been completely sequenced. SRV-4 was recovered once from cynomolgus macaques in California in 1984, but its genome sequences are unknown. Here we report the second identification of SRV-4 and its complete genome from infected cynomolgus macaques with Indochinese and Indonesian/Indochinese mixed ancestry. Phylogenetic analysis demonstrated that SRV-4 was distantly related to SRV-1, 2, 3, 5, 6 and 7. SRV/D-T, a new SRV/D recovered in 2005 from cynomolgus monkeys at Tsukuba Primate Center in Japan, clustered with the SRV-4 isolates from California and Texas and was shown to be another occurrence of SRV-4 infection. The repeated occurrence of SRV-4 in cynomolgus monkeys in different areas of the world and across 25years suggests that this species is the natural host of SRV-4.

| S-EPMC2941434 | biostudies-literature

Bartonella quintana in cynomolgus monkey (Macaca fascicularis).

Project description:We identified a Bartonella quintana strain by polymerase chain reaction amplification, cloning, and sequencing of DNA extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus monkey (Macaca fascicularis). This report describes naturally acquired B. quintana infection in a nonhuman primate.

| S-EPMC3367614 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data