T1DGC: Genome-Wide Association Study in Type 1 Diabetes, 2008

ABSTRACT:

Cases with Type 1 Diabetes (T1D) in the UK, were part of the Wellcome Trust Case Control Consortium (WTCCC) - http://www.wtccc.org.uk - that first reported in 2007:

Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678. [PubMed: 17554300]

In this genome-wide association study (GWAS), funded by the NIH and JDRF, and sponsored by the Type 1 Diabetes Genetics Consortium (T1DGC), we were able to extend the case and control groups used in the WTCCC, with the intention of performing a well-powered meta-analysis.

The study is written up as:

Barrett, J.C., Clayton, D.G., Concannon, P., Akolkar, B., Cooper, J.D., Erlich, H.A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, F., Schuilenburg, H., Smyth, D.J., Stevens, H., Todd, J.A., Walker, N.M., Rich, S.S. and The Type 1 Diabetes Genetics Consortium Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, PMID: 19430480.

Resources - data:

* Case data from this study is deposited here (i.e. in dbGaP)

* Control data from this experiment - with subjects from the 1958 British Birth Cohort - is deposited with the European Genotype Archive (EGA):

http://www.ebi.ac.uk/ega/

from where the WTCCC data is also available.

* A complete description of how to request all components of the meta-analysis is available at:

http://www.t1dbase.org/page/PosterView/display/poster_id/324

* Additional genetic data on the same case subjects, including some HLA types, are available from the Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT-DIL):

http://www-gene.cimr.cam.ac.uk/todd/

Resources - samples:

Case and control DNA samples are also available:

* Case DNA samples are available from the JDRF/WT-DIL, as above, and will be available from the NIDDK Genetics Repository at Rutgers:

https://www.niddkrepository.org

* Control DNA samples are available from the 1958 British Birth Cohort (aka National Child Development Study):

http://www.cls.ioe.ac.uk/studies.asp?section=000100020003

Use restrictions:

There are access limitations to both data and samples, in order to keep their use in line with subjects' consent.

PROVIDER: phs000180 | dbGaP |

SECONDARY ACCESSION(S): PRJNA75447PRJNA75445

REPOSITORIES: dbGaP