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The Genomic Complexity of Primary Human Prostate Cancer

ABSTRACT:

Seven primary prostate cancers and their paired normal counterparts were DNA-sequenced on a massively parallel sequencing platform. This approach was taken to investigate the genomes for mutations and genomic alterations that would be undetectable by lower-resolution methods. As result, tumors containing chains of balanced rearrangements that occurred within or adjacent to known cancer genes were discovered.

PROVIDER: phs000330 | dbGaP |

SECONDARY ACCESSION(S): PRJNA74911PRJNA74909

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs000330.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	phs000330.v1-Documents.zip	Other
	Study_Report.phs000330.ProstateCancer_Rubin.v1.p1.MULTI.pdf	Pdf
	manifest_phs000330.ProstateCancer_Rubin.v1.p1.c1.HMB-NPU.pdf	Pdf

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The Genomic Complexity of Primary Human Prostate Cancer

Project description:<p>Seven primary prostate cancers and their paired normal counterparts were DNA-sequenced on a massively parallel sequencing platform. This approach was taken to investigate the genomes for mutations and genomic alterations that would be undetectable by lower-resolution methods. As result, tumors containing chains of balanced rearrangements that occurred within or adjacent to known cancer genes were discovered.</p>

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