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Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers

ABSTRACT:

In this study, we describe a systematic analysis of pseudogene 'transcription' from an RNA-Seq resource of 293 samples, from 13 cancer and normal tissue types. We observed a highly prevalent, genome-wide expression of pseudogenes that could be categorized as universally expressed or lineage- and/or cancer-specific. We also explored disease subtype specificity and functions of selected expressed pseudogenes. We provide evidence that transcribed pseudogenes are a significant contributor to the transcriptional landscape of cells and are positioned to play significant roles in cellular differentiation and cancer progression. Our work provides a transcriptome resource that enables high-throughput analyses of pseudogene expression.

PROVIDER: phs000525 | dbGaP |

SECONDARY ACCESSION(S): PRJNA173131PRJNA173130

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs000525.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000525.CancersExpressedPseudogenes.v1.p1.MULTI.pdf	Pdf
	manifest_phs000525.CancersExpressedPseudogenes.v1.p1.c1.CRGM.pdf	Pdf
	datadict_v2.xsl	Other

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