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Bladder Cancer Clinical Cohorts

ABSTRACT:

Cisplatin-based chemotherapy is the standard of care for patients with muscle invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, and some patients with metastatic disease achieve complete responses to these therapies. However, the molecular determinants of cisplatin response are incompletely understood. We performed whole exome sequencing on tumor and germline DNA from patients with muscle invasive or metastatic urothelial carcinoma who received cisplatin-based chemotherapy to identify somatic mutations that occurred preferentially in cisplatin responders.

PROVIDER: phs000771 | dbGaP |

SECONDARY ACCESSION(S): PRJNA254087PRJNA254088

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs000771.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000771.BladderCancerClinicalCohorts.v1.p1.MULTI.pdf	Pdf
	manifest_phs000771.BladderCancerClinicalCohorts.v1.p1.c1.DS-BLADDERCA.pdf	Pdf
	manifest_phs000771.BladderCancerClinicalCohorts.v1.p1.c2.DS-GEN-URI-CA.pdf	Pdf

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