Genomic

Dataset Information

0

Post-Liver Transplant Recurrent Human Hepatocellular Carcinoma Study (RHCCS)


ABSTRACT:

The whole exome sequencing showed that HERC5 deletion and under-expression associates with shorter: time to tumor recurrence, progression-free, and overall survival in hepatocellular carcinoma (HCC) in two independent studies (p1=0.004, HR1=1.80; p2=0.018, HR2=3.31) totaling 286 HCC patients. Matched primary and recurrent tumors indicated a clonal selection advantage in somatic single nucleotide and copy number variants (CNVs) in recurrent compared to primary tumors of Chinese HCC patients with Wnt signaling most activated.

PROVIDER: phs000782 | dbGaP |

SECONDARY ACCESSION(S): PRJNA257122PRJNA257121

REPOSITORIES: dbGaP

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