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Paired AML Epigenetics Study on Clonality

ABSTRACT:

We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles). Methclone efficiently analyzes genome-wide DNA methylation sequencing data. We quantify the changes using a composition entropy difference calculation and also introduce a new measure of global clonality shift, loci with epiallele shift per million loci covered, which enables comparisons between different samples to gauge overall epiallelic dynamics. Finally, we demonstrate the utility of methclone in capturing functional epiallele shifts in leukemia patients from diagnosis to relapse. Methclone is open-source and freely available at https://code.google.com/p/methclone. Reprinted with permission from BMC Publishing (Genome Biology).

PROVIDER: phs000793 | dbGaP |

SECONDARY ACCESSION(S): PRJNA259810PRJNA259811

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs000793.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000793.ClonalityPaired_AML_Epigenetics.v1.p1.MULTI.pdf	Pdf
	manifest_phs000793.ClonalityPaired_AML_Epigenetics.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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