Dataset Information

Longitudinal Genome-Wide Analysis of Patients with Chronic Lymphocytic Leukemia

ABSTRACT:

Samples from two-center prospective phase 2 clinical trail conducted at Ohio State University (Columbus, OH) and Mayo Clinic (Rochester, MN) were analyzed in 12 cases. All patients had progressive CLL as defined by National Cancer Institute (NCI) Working Group criteria. Patients provided written informed consent for correlative studies according to the Declaration of Helsinki on an institutional review board approved protocol for the collection and use of samples for research purposes from both participating institutions. Eligible patients received a regimen consisting of pentostatin (2 mg/m2), cyclophosphamide (600 mg/m2), and rituximab (375 mg/m2) provided intravenously on day 1 of a 21-day cycle for a maximum of 6 cycles. Responses were assessed by NCI Working Group criteria and included a bone marrow evaluation and two-color flow cytometry 2 months after completion of therapy. Peripheral blood samples from these patients collected longitudinally before (Pre-Baseline), at (Baseline) and after therapy (Relapse) were analyzed for genomic heterogeneity and clonal complexity by high throughput Exome sequencing.

PROVIDER: phs000794 | dbGaP |

SECONDARY ACCESSION(S): PRJNA260233PRJNA260234

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs000794.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000794.Longitudinal_CLL.v1.p1.MULTI.pdf	Pdf
	manifest_phs000794.Longitudinal_CLL.v1.p1.c1.GRU-MDS.pdf	Pdf
	datadict_v2.xsl	Other

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Dataset Information

Longitudinal Genome-Wide Analysis of Patients with Chronic Lymphocytic Leukemia

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