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Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors

ABSTRACT:

Pancreatic neuroendocrine tumors (PNETs), often referred to as "islet cell tumors", are neuroendocrine neoplasms that arise from cells of the endocrine and nervous system within the pancreas. These rare tumors which originate from the pancreatic islet are divided into many categories and are often classified by the hormone most strongly secreted. With the collaboration of the Elkins Pancreatic Center, the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine had access to approximately 30 untreated tumor specimens and matched normal blood samples. Since the onset and progression of cancer is driven by extensive mutation of the genome, we are combining enrichment of exonic DNA with next generation sequencing to detect and characterize the somatic mutation profile of patients with pancreatic neuroendocrine cancer.

This work was done at the Human Genome Sequencing Center (HGSC) in collaboration with the Elkins Pancreatic Center at Baylor College of Medicine in Houston, TX and was supported by grant number 5U54HG003273 from National Human Genome Research Institute (NHGRI).

PROVIDER: phs000871 | dbGaP |

SECONDARY ACCESSION(S): PRJNA276395PRJNA276394

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs000871.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000871.PancreaticNeuroendocrineTumors.v1.p1.MULTI.pdf	Pdf
	manifest_phs000871.PancreaticNeuroendocrineTumors.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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