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DNA Methylation Inhibitors in Immunotherapy

ABSTRACT:

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway and re-expression of epigenetically silenced endogenous retrovirus. In melanoma patients treated with an immune checkpoint therapy, high viral defense signature expression in tumors significantly associates with durable clinical response and DNMTi treatment sensitizes to anti-CTLA4 therapy in a pre-clinical melanoma model.

PROVIDER: phs001038 | dbGaP |

SECONDARY ACCESSION(S): PRJNA305077PRJNA305076

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001038.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001038.DNA_MethylationInImmunotherapy.v1.p1.MULTI.pdf	Pdf
	manifest_phs001038.DNA_MethylationInImmunotherapy.v1.p1.c1.HMB-PUB-NPU-MDS.pdf	Pdf
	datadict_v2.xsl	Other

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