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NHLBI TOPMed: MGH Atrial Fibrillation Study

ABSTRACT:

The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained.

For the TOPMed WGS project only early-onset atrial fibrillation cases were sequenced. Early-onset atrial fibrillation was defined as an age of onset prior to 66 years of age.

Comprehensive phenotypic and pedigree data for study participants are available through dbGaP phs001001.

PROVIDER: phs001062 | dbGaP |

SECONDARY ACCESSION(S): PRJNA309735PRJNA309734

REPOSITORIES: dbGaP

ACCESS DATA

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001062.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	phs001062.v1-Documents.zip	Other
	Study_Report.phs001062.TOPMed_WGS_MGH_AF.v1.p1.MULTI.pdf	Pdf
	manifest_phs001062.TOPMed_WGS_MGH_AF.v1.p1.c1.HMB-IRB.pdf	Pdf

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MGH Atrial Fibrillation Study

Project description:The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained. The Massachusetts General Hospital (MGH) Atrial Fibrillation Study is utilized in the following dbGaP substudies. To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001001 Massachusetts General Hospital (MGH) Atrial Fibrillation Study. <ul> <li><a href="./study.cgi?study_id=phs001116">phs001116</a> MGH AF CHARGE-S</li> <li><a href="./study.cgi?study_id=phs001117">phs001117</a> MGH AF Exome Sequencing</li> <li><a href="./study.cgi?study_id=phs001118">phs001118</a> MGH AF Medical Resequencing</li> </ul>

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