Dataset Information

A Prognostic Role of APC in Colorectal Cancers

ABSTRACT:

Colorectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clinic-pathologic staging for decades. There is a need to molecularly stratify subpopulations of CRC to better predict outcome and assign therapies. Here we report targeted exome sequencing of 1,321 cancer-related genes on 468 tumor specimens, which identified a subset of 17 genes that best classify CRC, with APC (Gene ID: 324) playing a central role in predicting overall survival. APC may assume 0, 1, or 2 truncating mutations, each with a striking differential impact on survival. Tumors lacking any APC mutation carry a worse prognosis than single APC mutation tumors, but tumors with two APC mutations and KRAS (Gene ID: 3845) and TP53 (Gene ID: 7157) mutations confer the poorest survival among all the subgroups examined. Our study demonstrates a substantial prognostic role for APC and suggests that sequencing of APC may have clinical utility in the routine staging and potential therapeutic assignment for CRC.

PROVIDER: phs001111 | dbGaP |

SECONDARY ACCESSION(S): PRJNA319429PRJNA319430

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001111.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001111.ColorectalCancerMutation.v1.p1.MULTI.pdf	Pdf
	manifest_phs001111.ColorectalCancerMutation.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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A Prognostic Role of APC in Colorectal Cancers

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