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Detection of Genes Predisposing to Hematologic Malignancies

ABSTRACT:

We have been conducting genetic studies on families at high risk of different hematologic malignancies, in order to define the related tumors in the families, define precursor and other related conditions, and map and identify susceptibility genes. We have focused mainly on four types of lymphoid malignancies: chronic lymphocytic leukemia (CLL), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), and Waldenström macroglobulinemia (WM). A few families with a rare lymphoma subtype, hairy cell leukemia (HCL) are included. In addition, single large pedigrees with acute myeloid leukemia (AML), and juvenile myelomocytic leukemia (JMML) are included. Families are ascertained for having at least two patients with the same hematologic malignancy and are classified by the type of malignancy that predominates in the family. Multiple types of lymphoid malignancies are often found in the same family. Other data has shown that these conditions aggregate together in families. Verification of cancer diagnoses is obtained through medical records, pathology reports, and flow cytometry. Family members with precursor traits are also included, monoclonal B-cell lymphocytosis (MBL) in CLL families and IgM monoclonal gammopathy of undetermined significance (MGUS) in WM families.

PROVIDER: phs001219 | dbGaP |

SECONDARY ACCESSION(S): PRJNA344003PRJNA344002

REPOSITORIES: dbGaP

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Dataset's files

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			Action	DRS
	GapExchange_phs001219.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001219.FamilialBloodLymphNodeCancers.v1.p1.MULTI.pdf	Pdf
	manifest_phs001219.FamilialBloodLymphNodeCancers.v1.p1.c1.DS-CA-MDS.pdf	Pdf
	datadict_v2.xsl	Other

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