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Neoadjuvant Trastuzumab Response in Breast Cancer

ABSTRACT:

HER2 (ERBB2) gene amplification and overexpression are present in 15-30% of invasive breast cancers. While HER2-targeted agents such as trastuzumab are effective treatments, therapeutic resistance remains a concern in HER2-positive breast cancer with 40-50% of patients having residual disease after neoadjuvant treatment with chemotherapy and trastuzumab.

To investigate features that may make it possible to predict at diagnosis which cancers will be responsive to trastuzumab and chemotherapy, 48 tumor/normal DNA pairs extracted from pretreatment tumor biopsies and blood of HER2-positive breast cancer cases treated with neoadjuvant chemotherapy and trastuzumab were sequenced. Whole genome and exome sequence from tumor (average depth 49x and 71x) and normal (average depth 33x and 69x) DNA are included here as well as RNAseq data for 42 of the tumors. The study cohort was equally divided between patients who experienced pathological complete response and those with residual disease.

Samples were obtained from the American College of Surgeons Oncology Group Z1041 trial (NCT00513292) and a local single-institution study (NCT00353483).

PROVIDER: phs001291 | dbGaP |

SECONDARY ACCESSION(S): PRJNA371666PRJNA371665

REPOSITORIES: dbGaP

ACCESS DATA

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001291.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001291.NeoadjuvantTrastuzumab_BC.v1.p1.MULTI.pdf	Pdf
	manifest_phs001291.NeoadjuvantTrastuzumab_BC.v1.p1.c1.DS-CA.pdf	Pdf
	datadict_v2.xsl	Other

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