Dataset Information

Tibetan Population History and High Altitude Adaptation Study

ABSTRACT:

Due to a unique adaptation to high altitude, the Tibetan Plateau population has been the subject of much research interest. In this study, we conducted whole genome sequencing of 27 Tibetan individuals. Through our analysis, we inferred a detailed history of demography and revealed the natural selection of Tibetan population. We provided evidence of genetic separation between the two subpopulations of Han and Tibetans as early as 44 to 58 thousand years ago, replicated previously reported high altitude adaptation genes, including EPAS1 and EGLN1, and reported three new candidate genes, including PTGIS, VDR, and KCTD12.

PROVIDER: phs001338 | dbGaP |

SECONDARY ACCESSION(S): PRJNA380443PRJNA380444

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001338.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	phs001338.v1-Documents.zip	Other
	Study_Report.phs001338.Tibetan_WGS.v1.p1.MULTI.pdf	Pdf
	manifest_phs001338.Tibetan_WGS.v1.p1.c1.GRU-IRB.pdf	Pdf

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Tibetan Population History and High Altitude Adaptation Study

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