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Biological Insights from the genome Sequences of Human Embryonic Stem Cell Lines

ABSTRACT:

Human embryonic stem cells (hESCs) are a powerful tool for the study of human development and can form the basis of cellular disease models or therapies. However, the genetic make-up and stability of hESCs has not been systematically studied at a genome-wide level with single nucleotide resolution. We therefore sequenced the whole exomes of widely available hESCs. The data generated has provided new insights about the nature of acquired variation and the genomic integrity of the cell lines. We anticipate that this online resource will enable investigators to access raw sequencing data in order to interrogate cell lines for different disease and trait-associated genetic variants.

PROVIDER: phs001343 | dbGaP |

SECONDARY ACCESSION(S): PRJNA381257PRJNA381258

REPOSITORIES: dbGaP

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Dataset's files

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			Action	DRS
	GapExchange_phs001343.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001343.ES_CellLinesBiologicalInsights.v1.p1.MULTI.pdf	Pdf
	manifest_phs001343.ES_CellLinesBiologicalInsights.v1.p1.c1.GRU.pdf	Pdf
	manifest_phs001343.ES_CellLinesBiologicalInsights.v1.p1.c2.HMB.pdf	Pdf

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