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GnRH Agonist-Induced Ovarian Suppression and Ovarian Steroids in PMDD and Controls

ABSTRACT:

In this study, lymphoblastoid cell line cultures (LCLs) from women with premenstrual dysphoric disorder (PMDD) and asymptomatic controls were compared via whole-transcriptome sequencing (RNA-seq) during untreated (ovarian steroid-free) conditions and after estradiol and progesterone treatment. In untreated LCLs, pathway analysis of the LCL transcriptome revealed, among others, over-expression of ESC/E(Z) complex genes (an ovarian steroid-regulated gene silencing complex) with significant overexpression of MTF2, PHF19, and SIRT1 (P<0.05) in cells from women with PMDD compared with controls. Finally, mRNA expression of several ESC/E(Z) complex genes were increased by progesterone in controls only, and decreased by estradiol in PMDD LCLs.

PROVIDER: phs001344 | dbGaP |

SECONDARY ACCESSION(S): PRJNA381261PRJNA381262

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001344.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001344.GnRH_AgonistInduced_PMDD.v1.p1.MULTI.pdf	Pdf
	manifest_phs001344.GnRH_AgonistInduced_PMDD.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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