Dataset Information

NHLBI TOPMed: Cardiovascular Health Study

ABSTRACT:

Participants from the Cardiovascular Health Study (CHS), a large population-based longitudinal cohort study ( phs000287), have been included in the TOPMed project. Whole genome sequencing will be performed to contribute to multiple analyses, including cardiovascular disease risk factors, subclinical disease measures, the occurrence of myocardial infarction (MI) and stroke, and analyses of venous thromboembolism (VTE).

PROVIDER: phs001368 | dbGaP |

SECONDARY ACCESSION(S): PRJNA397104

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001368.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	phs001368.v1-Documents.zip	Other
	Study_Report.phs001368.TOPMed_WGS_CHS_VTE.v1.p1.MULTI.pdf	Pdf
	manifest_phs001368.TOPMed_WGS_CHS_VTE.v1.p1.c1.HMB-MDS.pdf	Pdf

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Project description:Objectives The Cardiovascular Health Study (CHS) is a study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The objectives of the Cardiovascular Health Study are to: 1) quantify associations of conventional and hypothesized risk factors with CHD and stroke; 2) assess the associations of non-invasive measures of subclinical disease with the incidence of CHD and stroke; 3) quantify the associations of risk factors with subclinical disease; 4) characterize the natural history of CHD and stroke, and identify factors associated with clinical course; and 5) describe the prevalence and distributions of risk factors, non-invasive measures of subclinical disease, and clinical CHD and stroke. Background The study originated in 1988 from the recommendations of an NHLBI workshop on the management of CHD in the elderly. This is the most extensive study undertaken by the NHLBI to study CVD exclusively in an elderly population. Initially funded for six years, it was renewed for a second six year period in 1994 and recently was renewed with limited support for the Coordinating Center, the Laboratory and the Steering Committee. Grant funding from several sources has supported an additional clinic visit in 2005-2006 and continued morbidity and mortality follow-up. Subjects The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort totaled 5,201 participants. A new cohort was recruited in 1992. The 687 participants in the new cohort are predominately African-American and were recruited at three of the four field centers. Design The 2,962 women and 2,239 men were examined yearly from 1989 through 1999. The added minority cohort of 256 men and 431 women was examined from 1992 to 1999. Examination components have included medical history questionnaires, measurement of ankle-brachial index, abdominal and carotid ultrasound studies, echocardiograms, ambulatory electrocardiograms, cerebral magnetic resonance imaging, spirometry and retinal photographs over the past decade. The most extensive evaluations were at study entry (baseline) and again in 1992-1993 to assess change in subclinical disease measures. CHS has undertaken extensive follow-up for ascertainment of cardiovascular events including incident claudication, myocardial infarction, congestive heart failure, stroke and death. Genetic Research The Cardiovascular Health Study has expanded its research mission into the study of genetic factors underlying CVD and other disorders using DNA that was collected from blood samples from most participants. Subsets of CHS participants have been genotyped in large-scale genotyping projects, including thousands of SNP genotypes for candidate gene regions as part of the NHLBI Candidate gene Association Resource (CARe) and genome-wide genotyping as part of the NHLBI SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED). Whole exome sequencing of an overlapping subset of CHS participants was performed through the NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP). The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs000287 Cardiovascular Health Study Cohort. <li><a href="./study.cgi?study_id=phs000226">phs000226</a> STAMPEED: Cardiovascular Health Study (CHS)</li> <li><a href="./study.cgi?study_id=phs000301">phs000301</a> PAGE: CaLiCo: Cardiovascular Health Study</li> <li><a href="./study.cgi?study_id=phs000377">phs000377</a> CARe Cardiovascular Health Study</li> <li><a href="./study.cgi?study_id=phs000400">phs000400</a> GO-ESP-CHS: Cardiovascular Health Study Component of the Exome Sequencing Project</li> <li><a href="./study.cgi?study_id=phs000667">phs000667</a> CHARGE-S: Cardiovascular Health Study (CHS)</li>

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NHLBI TOPMed: Cardiovascular Health Study

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